ea0035p491 | Diabetes therapy | ECE2014
Li Li
, Gu Weiqiong
, Ye Lei
, Yang Minglan
, Wan Bin
, Hong Jie
, Wang Weiqing
, Ning Guang
Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a promising treatment to reverse type 1 diabetes (T1D) in patients with significantly improved β-cell function. This study was designed to investigate the potential immunological mechanisms involved.Design and methods: 18 newly-diagnosed T1D were divided into two groups, the AHSCT group and the insulin therapy group. Blood mononuclear cells (PBMCs) of the patients at the baseli...